Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

$16.98

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Price: $16.98
(as of Nov 07, 2025 04:37:57 UTC – Details)


Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they dont have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.
Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.
That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It’s easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.
For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment.
Advantage II Large Cat is a trademark of Elanco or its affiliates.

Product Dimensions ā€ : ā€Ž 4.25 x 0.87 x 4.72 inches; 0.69 ounces
Item model number ā€ : ā€Ž 90204382
Date First Available ā€ : ā€Ž March 27, 2019
Manufacturer ā€ : ā€Ž Elanco US Inc
ASIN ā€ : ā€Ž B07N9LSPRY
Best Sellers Rank: #1,225 in Pet Supplies (See Top 100 in Pet Supplies) #10 in Cat Flea Drops
Customer Reviews: 4.4 4.4 out of 5 stars 6,368 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

Customers say

Customers find the flea treatment effective at killing fleas and appreciate its ease of application. The product receives positive feedback for flea control, with one customer noting it’s better than flea collars. However, experiences with skin irritation and hair loss are mixed, with some reporting no skin issues while others experience burns and patches of hair loss. The product’s lifespan and effectiveness against fleas are also mixed, with some saying it doesn’t last long and others reporting their cats still have fleas. Value for money opinions are divided, with some finding it good value while others say it’s not worth the cost.

8 reviews for Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

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  1. Verified Amazon Customer

    IT WORKS! 24 hours after application and NO LIVE FLEAS.
    I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it’s a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there’s a very good chance of bringing fleas in with you without ever knowing.Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential!My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money.A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn’t get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets.We did NOT want to put her in the bathtub. I mean, if you’ve ever bathed a cat in less than a full suit of armor, you know what I’m talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath “does” kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn’t jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn’t acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn’t want to stress her out even more by doing more combing.Enter Advantage II Large Cat.I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad…and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn’t work, she was going to get a water bath…and I don’t have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire…which is essentially the same thing.I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her.It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she’s not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product.I will continue to be diligent with the flea comb to see if she needs another treatment next week.Knowing what I know now, I wish I wouldn’t have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry.I highly recommend this product.Note: If one is worried about their cat’s skin, I recommend using one or two drops to “test” how your cat will react to it before giving the full dose.

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  2. Stacey M

    Absolute miracle for my cat’s itching — worked in 48 hours!
    I can’t say enough good things about this product. My cat had been scratching nonstop for over a week, leaving scabs and looking so uncomfortable. I tried everything — different food, brushing, wipes — nothing worked. Then I found this product, and within 48 hours of using it, her itching completely stopped!It was unbelievably easy to apply, and she didn’t mind it at all. Her skin looks so much better now, and her fur is already starting to grow back where she’d scratched. I’m genuinely amazed — this stuff is a total miracle in a bottle.If your cat is dealing with itching or irritation, do yourself (and your kitty!) a favor and get this. I’ll never be without it again!

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  3. Kelly

    Effective
    I’ve used this on our outdoor TNR cats for years. It keeps the fleas off of them. I’ve only had one cat that had a skin reaction to it. He lost hair at the application site. None of the others ever had a problem.

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  4. Maddie Cobb

    Works good
    My cat started having a bad reaction to his old flee medicine so I tried this one and so far so good! I just wish it had tick protection too because he is a barn cat.

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  5. Andy

    Efectivo.
    t’s a very good product. My kitten had fleas and it worked very well. It didn’t irritate or cause allergies, and the fleas went away. I recommend it.

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  6. VOrrego

    Works Great!
    I tried Frontline and it only got rid of some fleas on my 2 cats. I tried a flea bath and the same. Finally I tried Advantage 2 both for my small cat 6lbs and my large cat 10lbs. Within 3 hours fleas were falling off both cats. Thank you for this product

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  7. Amazon Customer

    May be a dupe
    Useless. 3 days later and there are still live, active fleas. Who knows if this stuff is even the real deal when youre buying online.

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  8. Laura Torres

    It’s ok
    Could work better

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    Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply
    Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

    $16.98

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