Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply

$66.98

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Price: $66.98
(as of Oct 12, 2025 13:08:59 UTC – Details)


Advantage II Extra Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Extra Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Extra Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.
This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Extra Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.
That’s why Advantage II topical, spot-on formula makes application simple – going on in seconds. It’s easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
Advantage II Extra Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use Advantage II Extra Large Dog.
For the ultimate convenience in care, Advantage II Extra Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Extra Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.
Advantage II Extra Large Dog is a trademark of Elanco or its affiliates.
Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 2.56 ounces
Item model number ‏ : ‎ 86336669
Department ‏ : ‎ Flea & Tick
Date First Available ‏ : ‎ March 5, 2011
Manufacturer ‏ : ‎ Elanco US Inc
ASIN ‏ : ‎ B004QRJJF0
Best Sellers Rank: #4,443 in Pet Supplies (See Top 100 in Pet Supplies) #34 in Dog Flea Drops
Customer Reviews: 4.5 4.5 out of 5 stars 6,603 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Vet recommended flea treatment and prevention for dogs at weighing over 55 lbs., at least 7 weeks of age
Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
Easy-to-apply topical treatment, no prescription needed
Fragrance-free formula, waterproof after 24 hours

Customers say

Customers find the flea treatment effective, keeping fleas and ticks away completely, and consider it the best product available, better than Frontline. The product is easy to apply, safe for both dogs and cats, and offers good value for money. Regarding skin irritation and longevity, experiences are mixed – while some report their dogs scratching and itching less after application, others note it doesn’t last more than two weeks.

8 reviews for Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply

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  1. Vin

    I purchased the dog version for my cats because it works a lot better.
    We do not have dogs we actually have cats but what we found out was if we use the dog version as this box on our cats it gives them a better coverage. The only problem that I see with our cats are: 1 the cats still jump when you touch around their back side, after using a flea comb they still have a few fleas. 2 the cats seem to be more relaxed at least until you touch them in certain areas. Without this chemical cancer constantly scratching themselves.

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  2. Noah

    How to Use the “Extra Large Pack” to dose multiple dogs! Saves money on this great product!
    I live in the American South, and my vets agree that Advantage works better than Frontline or any generic products. To get the most value for your money, I recommend buying the dosage for extra-large dogs and splitting it among smaller dogs. Save a small jar such as for pimentos or olives. Ask your pharmacist for a plastic dosing syringe (the kind for giving kids liquid medicine); they will likely give you one. I’ve attached a sample picture of the type of syringe you need. You need one without a needle that holds the amount of ML you will be using, based on the below guidelines.Take off your dog’s collar to ensure it doesn’t slide down onto where you will be putting the Advantage. Open a package of Advantage and pour it into the jar. Pull into the syringe the right amount for your dog’s weight:0.4ml = 0-10#0.8ml = 11-20#1.2ml = 21-30#1.6ml = 31-40#2.0ml = 41-50#2.4ml = 51-60#2.8ml = 61-70#3.2ml = 71-80#You will put part of the Advantage on the dog’s neck, and part of it in a few places down his back. Use your fingers to part the dog’s hair on the back of his neck. (See package instructions on where to place the treatment.) Slowly depress the plunger onto the skin, NOT on top of the hair. Otherwise, it will drip off of the hair. Do several more spots down the dog’s spine.Immediately give treats to keep them from shaking their heads around. I learned the hard way that, if your dog vigorously shakes, this product can take the paint off cabinets and the varnish off stainless steel!! I do the treatment outside and leave the dogs outside for an hour or so.Buying the largest size of Advantage and dosing several dogs with it can save a lot of money in the long run. Let’s say your dog weighs 32 lbs, and you purchase the “Large dog for pets 21-55 lbs” and put the entire tube on him. You will be giving him 2.5 ML when he really only needs 1.6 ML. In a home with several dogs, this can add up!Of course, talk to your vet if you have questions. This is just how I do it at my house! I am not a vet. I plan to post a video showing how I use this method.**I have relied heavily on reviews for years, since I do most of my shopping online. I’ve finally starting trying to return the favor by writing reviews of products I love. I hope my review was helpful to you!**

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  3. Mark Blair

    Great job
    Great and product

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  4. Daytripper23

    Pretty Good Flea Collars
    Pretty Good flea collar. I like that there are more in the box..Stella is more comfortable now. She is so grouchy anyhow, it’s hard to tell lol

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  5. Heather Coltrin

    Thank you!!
    Thank you for refunding our money on one of our lost orders!!! Will keep ordering from you every year !!! LOVE THIS PRODUCT AND COMPANY

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  6. Donna

    Good
    Why did you pick this product vs others?:Good 

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  7. Vikki moelhman

    Works on battle with fleas
    I have always used Advantage on my two cats and one dog. I just adopted a pit and started her out on this as soon as she got home, since spring is right around the corner. works and she has no side effects, except for no fleas.

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  8. leslie

    Bought this for my cats(yes, cats)
    I’ve been dosing down advantage for 2 decades. Sad that multi seems gone as it got 3 types of parasites including tapeworm which often follows flea infestations. YOU CANNOT DO THIS WITH ADVANTIX. As long as the percentage of the active ingredients is the same on the dogs as it is with the cats, it’s only a matter of dosage size(you can do this with Frontline too but to me they’re as good as hartz in efficacy) so my kitten(2-5lbs) gets 0.23ml and my massive fat cat(over 9lbs) gets 0.8ml. Cats that are 5-9lbs would get 0.4ml. Saves quite a lot.

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    Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply
    Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply

    $66.98

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