Apex Plus Flea and Tick Prevention for Dogs | Large (45-88 lbs) | 6-Month Supply | Dog Flea and Tick Treatment | 24-Hour Activation, Waterproof, 30-Day Protection
$23.49








Price: $23.49
(as of Dec 01, 2025 02:32:07 UTC – Details)
From the brand

Apex Plus for Dogs
Value, Quality, and Protection
VALUE
At Apex Animal Health, we strive to bring you the best value products without compromising quality.
QUALITY
Quality products at an affordable price. We take pride in providing the best products at the best prices.
PROTECTION
We strive to provide your pet with flea and tick protection at a price point that fits the budget.
Product Dimensions ā : ā 5.75 x 1 x 4.38 inches; 1.45 ounces
Date First Available ā : ā January 14, 2024
Manufacturer ā : ā Apex Animal Health
ASIN ā : ā B0CNJ1RW2X
Best Sellers Rank: #8,786 in Pet Supplies (See Top 100 in Pet Supplies) #40 in Dog Flea Drops
Customer Reviews: 4.0 4.0 out of 5 stars 2,015 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
EFFECTIVE DOG FLEA & TICK CONTROL ā Apex Plus flea and tick prevention for dogs kills adult fleas and also targets flea eggs, larvae, and prevents the development of flea pupae, ensuring a thorough elimination of fleas at all life stages. With tailored formulations for dogs weighing 5-22 lbs (Small), 23-44 lbs (Medium), 45-88 lbs (Large), and 89-132 lbs (X-Large), Apex Plus dog flea medicine offers a customized solution for various sizes, providing precise and effective protection.
CIRCUMSTANCES FOR TREATMENT ā Large dog flea treatment deals with addressing an existing infestation. When you’re treating dog fleas or ticks, you’re typically aiming to eliminate the parasites that are already present on the animal’s body. Severe infestations may require veterinary input for effective treatment and subsequent preventative measures.
CIRCUMSTANCES FOR PREVENTION ā Large dog tick prevention focuses on keeping the infestation from occurring in the first place. Preventive measures are aimed at stopping the parasites from ever becoming a problem. Dog flea and tick prevention is proactive and aims to keep the parasites away before they become an issue.
INSECT GROWTH REGULATOR (IGR) ADVANTAGE ā The inclusion of (S)-methoprene as an IGR sets Apex Plus dog flea treatment apart by preventing flea eggs from hatching and interrupting the insect’s life cycle, enhancing the product’s efficacy in controlling infestations. The combination of Fipronil and (S)-methoprene works synergistically to attack the nervous systems of fleas and ticks while inhibiting the maturation of flea eggs and larvae, effectively breaking the flea life cycle.
TOPICAL APPLICATION THAT’S SAFE FOR YEAR-ROUND USE ā Apex Plus topical flea treatment for dogs is easy to apply, making the treatment process convenient for pet owners. The product is dispersed over the pet’s body by natural skin oils, ensuring even coverage. Designed for monthly application, Apex Plus flea medication for dogs provides a year-round repellent against fleas and ticks, maintaining the health and well-being of your pet.
LONG-LASTING WATERPROOF PROTECTION FORMULA ā A single application of this flea medicine for dogs provides 30 days of continuous protection against fleas, ticks, and chewing lice, offering a hassle-free solution for pet owners. Apex Plus flea prevention for dogs becomes waterproof just 24 hours after application, ensuring efficacy even if your dog gets wet. This feature adds convenience for pet owners dealing with active dogs or living in rainy climates.
THE VALUE YOUR PET DESERVES ā Comprehensive and clear user guidelines are provided for each weight range, addressing common concerns such as bathing, application frequency, and potential interactions, ensuring pet owners have the safety and reliability information they need for proper use.
Customers say
Customers find the flea and tick treatment easy to apply and praise its quality. The effectiveness and flea control receive mixed feedback – while some say it works as well as veterinary-grade treatments, others report it doesn’t work at all or attracts fleas. The value for money is also mixed, with some finding it good for the price while others consider it a waste of money. Skin irritation is a concern, with many reporting their dogs scratching like crazy, and the product’s longevity is inconsistent, with some saying it lasts while others find it not long-lasting. Several customers report receiving completely empty tubes.
8 reviews for Apex Plus Flea and Tick Prevention for Dogs | Large (45-88 lbs) | 6-Month Supply | Dog Flea and Tick Treatment | 24-Hour Activation, Waterproof, 30-Day Protection
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$23.49


Yolonda –
get rid of fleas fast
haven’t notice no fleas on dog since using Apex also took my dog to groomer for flea bath and no fleas were found and that was only from one application will be applying the second application in a week’s time very satisfied with this product. I also stripped, cleaned and spayed flea spray in cage washed mats sprinkled carpet powder on them and put the cage and my dog outside for a few weeks to be able to sanitize house properly with spray and carpet vacuuming also sprinkled flea carpet powder on the rugs a week after spraying for as much defense as possible all is well with dog and space free of fleas
Bryce Pinkerton –
Good price
I find this to work the best out of all the cheapest options that actually it’s a pretty good Fleet control.
Vic –
Worthless. Don’t waste your money!
I purchased a pack of 6 for my 4 dogs after seeing fleas on them. and they were relentlessly itching , biting and scratching themselves. I administered it on the day that it arrived expecting they would be relieved. I washed their beds they sleep on because i have tile floors. 3 days later there was zero relief for any of them. I turned one over and fleas were running on her belly. I looked at the next one and found fleas on her also. All 4 got zero relief from fleas. Now i am afraid of giving them something else because of the build up in chemicals that break the blood barrier so i am left to use shapoos for another month until I find something that actually works.This product is worthless.If you are going to put chemicals on your dog get something that actually works. I threw the other 2 doses in the trash.
Anna –
Effectiveness Review
Easy application and use. After 2 days of the initial application I bathed my dog to see if he still had fleas. Found one big flea. I would still say there was progress as he had a quite a few before. Either the effectiveness takes time or it isn’t as effective as I expected in killing all the fleas.
B. Unwrenched –
An excellent produce in every way!
My 95-pound, six year old outdoor guard dog is covetous of his very large, fenced in, backyard exclusive domain. I know from experience, that his well being must, without question, include appropriate flea and tick preventative control applications. This product is highly tolerable, imparting confidence and trust in result. It is an excellent cost effective value for the quality and price. So nicely it is that this product also prevents him from scratching. It is great as well, that I don’t need to “scratch” the bottom of my pockets to pay for it! Thank You and Best Regards.
Jeannie Byrd –
Doesn’t do the job
Did not do the job. I put this on my lab/boxer mixed dog. The fleas are still there. I also used the capstar (which started out as being really good and then it lost its effect). So from now on I will used my vet.
Tonya Sanchesviesca –
Works as it should with no irritation.
I have six dogs and this is the only flea and tick meds I use. It keeps them comfortable even in the deep woods of Georgia!
Leslie –
Excellent Product
Works Great!