K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply
$18.98
Price: $18.98
(as of Sep 14, 2025 23:39:47 UTC – Details)
K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they canāt lay eggs and they donāt have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. Thatās why K9 Advantix II Large Dog topical, spot-on formula makes application simple – going on in seconds. It’s easier than a flea collar and there are no hard-to-swallow pills. Youāll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use K9 Advantix II Large Dog. For the ultimate convenience in care, K9 Advantix II is available over the counter ā no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park. K9 Advantix II Large Dog is a trademark of Elanco or its affiliates.
Product Dimensions ā : ā 4.25 x 0.88 x 4.75 inches; 0.01 ounces
Manufacturer recommended age ā : ā 1 month and up
Item model number ā : ā 90204385
Date First Available ā : ā March 13, 2019
Manufacturer ā : ā Elanco US Inc
ASIN ā : ā B07NX5BJK8
Best Sellers Rank: #355 in Pet Supplies (See Top 100 in Pet Supplies) #5 in Dog Flea Drops
Customer Reviews: 4.4 4.4 out of 5 stars 42,787 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
Kills fleas within 12 hours of application
Vet-recommended formula kills & repels on contact so fleas donāt have to bite your dog to die
Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
No prescription needed
Customers say
Customers find the flea and tick treatment highly effective, with no fleas or ticks reported and quick results. The product receives positive feedback for its quality, being recommended by veterinarians and better than alternatives like Frontline. While some customers report no skin irritation and no adverse reactions, others experience skin irritation and violent illness. The product’s durability is mixed, with some reporting it lasts a month while others say it doesn’t hold up for 30 days, and opinions on value are divided between those who find it a great value and those who consider it expensive.
4 reviews for K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply
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A. Waldron –
Worked well for Fluke
I recently moved from the cooler, mountainous region of SC to the warmer climate of middle GA to attend graduate school. I had been using Comfortis for two and half years on my dog, Fluke, without any problems. However, about two weeks ago, I felt a lump on her neck, and upon inspection, I discovered a tick. I began looking all over her body for more of these little pests, and found four more of them. Fortunately, Fluke is a rescue from a vet, and I don’t have to bear the burden of expensive vet bills when something like this situation occurs. I was told that the Comfortis does not necessarily guard against ticks, and while it may have been effective in SC, the tick population in the heavily wooded river area in which I live now might be too much for the tablet to protect against for Fluke. I bought this product because it proffered to prevent ticks from attaching to the dog, and thus far, it has proven quite effective. Fluke, as her name suggests, is an unusual 25 pound lab/pit mixture. I purchased the product in the larger size because she is in between the medium and large dosing sizes, and I wanted to be sure that she had adequate protection. Fluke has been her usual happy self since I applied it to her. The directions indicated that you should apply in four to six spots on the dog, and I chose to apply to six, as to not have too high of a concentration in any area. I know that some people have reported having adverse reactions upon applying this product on their dogs, but I have noticed a trend in the reviews: most of the reviews are concerning smaller dogs. It might be that the formula is just too much for a smaller dog, but I’m not anywhere near an expert on the topic, just something that I have noticed. I am of the opinion that what it boils down to is this: all dogs are different, and what works well for one dog does not necessarily work well for others; the same could be said of medications for people, too. I’m just happy to have chosen a product that works well for Fluke. On another note, if you only need flea prevention, Comfortis is amazing, and much less messy than the topical products. While searching for more ticks, I never did find a flea on her! I hope that my review could be of some help, even though it is not very specific.UPDATE AS OF JULY 2013: I have brought home a 4 pound Pomeranian since my original post. I stand by what I stated in my previous post: this product works well for fleas, ticks, and mites in the warmer climate of middle Georgia in which I live. Barnaby, my little Pomeranian, has not had an adverse reaction to this medication, and Fluke, my lab/pit mixture, remains free of fleas and ticks, all the while not exhibiting any negative symptoms. For my little Pomeranian, I applied the medication to 4 separate places along his back, again to not have too high of a concentration in any one area. I purchased the smallest dose currently on the market, and although it was a little high for his small stature, it did not seem to phase him in any sort of negative ways. I wait, at a minimum, 72 hours before bathing my dogs, and I also do not bathe them for at least 5 days prior to application of the medication, as the oils within a dog’s skin distribute the topical treatment. My dogs tolerate this medication well, and I have not found a flea or tick on either of them since I began using this product; however, I still will caution potential purchasers of this product: this product may not work well for your dog, just as some medications may not work well for you. Please, before you condemn the product as unsatisfactory, try to determine, and this may require the aid of a veterinarian, what your particular dog requires based upon breed, climate, and tolerance to topical flea prevention. I can only relate that this product works well for my larger dog and also my smaller dog within the area in which we currently live. Again, I hope that my update as to the effects of this product upon my smaller dog is helpful in your search for the right fit for your dog.
Amazonshopper –
It works
My dog was on a prescription medication before this. I had to stop her previous medication because it was out of stock for a while and when it was restocked, the price skyrocketed to $250 for a 6 month supply instead of the usual $120 that it was prior. There was a new generic version of her prescription but after reading the reviews on that, I didnāt want to risk my dogās health. During that time of her not being on any preventative, we ended up with a flea problem in my area which we never had before. Since the fires, a lot of wildlife has been dropping by in my neighborhood and with wildlife comes fleas just hitching a ride with them. We fell victim to an infestation in our backyard and surrounding areas. I panicked and tried the holistic approach for months with DE, changing my dogās diet, essential oils, etc to no avail. I had to try something because my dog is old and I really didnāt want to stress her by taking her to the vet for yet another prescription (which all had extremely negative adverse effects after doing plenty of research). I decided to try an OTC flea treatment and it was between this one and frontline. After doing more research, I opted for Advantix II since it was more effective than frontline (for my area). So glad I did because fleas were gone within a day. My dog has been on this for a year now and so far it is working. I did find a flea on her the other day right after we got back inside from our little walk and was able to grab it. I put it in a ziplock bag with a piece of my dogs shedded fur just to see if the treatment was still working since it had been 26 days since I used Advantix and within 2 hours of that flea crawling on her fur in that bag, it was dead. So I know for sure that this medication is working and working effectively at that. She was groomed two days prior to me finding a flea on her as well (she had a waterless bath and is wiped down with her dog wipes daily) – the bath and wipes didnāt minimize the effectiveness of this flea medication which is a huge plus! What Iāve learned throughout this whole process is that no treatment is going to immediately kill or prevent fleas or ticks – not even prescription medication – Advantix has saved me hundreds if not thousands of dollars on prescriptions and itās still as effective as a prescription. Itās a win – win in my book and I will continue to use this year round to keep my dog protected.
Eric T. –
Reliable ProtectionāNo Fleas, No Ticks, No Worries
K9 Advantix II has been our go-to for years when it comes to protecting our dogsāespecially with all the outdoor time they get on the farm. It works fast and effectively against fleas, ticks, and mosquitoes, and weāve had zero issues since using it consistently.The application is simple: just part the fur and apply it along the back. It dries quickly and doesnāt leave a greasy mess. What I really appreciate is that it repels pests before they even bite, which gives me peace of mindāespecially in the warmer months when ticks are everywhere.Our dogs havenāt had any adverse reactions, and theyāre outside constantlyārunning through tall grass, woods, and around livestock. Itās held up through baths and light rain too, which is a big plus.If you live rurally or have active outdoor dogs, this is one of the best defenses out there. Worth every penny for the protection it provides.
Amazon Customer –
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